HLA-B locus polymorphism: studies with a specific hybridization probe.
نویسندگان
چکیده
منابع مشابه
High-resolution analysis of the human HLA-DR polymorphism by hybridization with sequence-specific oligonucleotide probes.
The human major histocompatibility complex class II antigens of the HLA-D are highly polymorphic, surface proteins essential in the cellular interactions necessary for an immune response. The analysis of this polymorphism is crucial for (i) histocompatibility matching for transplantation and (ii) understanding the association between HLA-D and certain important diseases. The polymorphism of cer...
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The identification of broad classes of DNA probes which detect hypervariable genetic markers in different taxa is invaluable for parentage analysis in wild vertebrates. Restriction-fragment-length polymorphisms, detected by hybridization of a mouse class II major histocompatibility complex (MHC) cDNA probe to genomic DNA from red-winged blackbirds (Ageluius phoeniceus), are shown to have the ge...
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Diversity in 39 HLA-A, -B, and -C molecules is derived from 20 amino acid positions of high variability and 71 positions of low variability. Variation in the structurally homologous alpha 1 and alpha 2 domains is distinct and may correlate with partial segregation of peptide and T-cell receptor binding functions. Comparison of 15 HLA-A with 20 HLA-B molecules reveals considerable locus-specific...
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The HLA-C locus remains an enigma. The serological polymorphism is poorly defined, HLA-C molecules are expressed at the cell surface at about 10% the levels of HLA-A and -B, and their importance for antigen presentation to either CD8-bearing T cells or natural killer cells is unclear. Our understanding of HLA-C polymorphism has also lagged behind that of HLA-A and -B. We have applied the polyme...
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A random sample of 500 healthy unrelated subjects from Esfahan province were HLA typed for A, 8 and C locus antigens. The lymphocytes were separated from 5 ml of whole peripheral blood and were typed for HLA _ A, 8 and C by using the standard two stage microlymphocytotoxicity NIH technique. The findings suggest that in the study population, frequency of HLA-Al' A2, A3, Ag HLA-8s, 83S and HLA-CW...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1985
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.82.24.8614